For any project enquiries phone +49 (0)761 76 999 422
My publications
Blüher, M., Saunders, S. J., Mittard, V., Torrejon Torres, R., Davis, J. A., & Saunders, R. (2019). Critical Review of European Health-Economic Guidelines for the Health Technology Assessment of Medical Devices. Frontiers in Medicine, Section Regulatory Science.
Davis, J. A., Saunders, S. J., Mann, M., & Backofen, R. (2017). Combinatorial ensemble miRNA target prediction of co-regulation networks with non-prediction data. NAR, 45(15), 8745–8757.
Reimann, V., Alkhnbashi, O. S., Saunders, S. J., Scholz, I., Hein, S., Backofen, R., & Hess, W. R. (2017). Structural constraints and enzymatic promiscuity in the Cas6-dependent generation of crRNAs. NAR, 45(2), 915–925.
Del Vecchio, G., De Vito, F., Saunders, S. J., Risi, A., Mannironi, C., Bozzoni, I., & Presutti, C. (2016). RNA-binding protein HuR and the members of the miR-200 family play an unconventional role in the regulation of c-Jun mRNA. RNA, 22(10), 1510–1521.
Alkhnbashi, O. S., Shah, S. A., Garrett, R. A., Saunders, S. J., Costa, F., & Backofen, R. (2016). Characterizing leader sequences of CRISPR loci. Bioinformatics, 32(17), i576–i585.
Holzer, M., Krahling, V., Amman, F., Barth, E., Bernhart, S. H., Carmelo, V. A. O., Collatz, M., Doose, G., Eggenhofer, F., Ewald, J., Fallmann, J., Feldhahn, L. M., Fricke, M., Gebauer, J., Gruber, A. J., Hufsky, F., Indrischek, H., Kanton, S., Linde, J., … Marz, M. (2016). Differential transcriptional responses to Ebola and Marburg virus infection in bat and human cells. Sci Rep, 6, 34589.
Maier, L.-K., Stachler, A.-E., Saunders, S. J., Backofen, R., & Marchfelder, A. (2015). An active immune defense with a minimal CRISPR (clustered regularly interspaced short palindromic repeats) RNA and without the Cas6 protein. JBC, 290(7), 4192–4201.
Preusse, M., Marr, C., Saunders, S., Maticzka, D., Lickert, H., Backofen, R., & Theis, F. (2015). SimiRa: A tool to identify coregulation between microRNAs and RNA-binding proteins. RNA Biology, 12(9), 998–1009.
Makarova, K. S., Wolf, Y. I., Alkhnbashi, O. S., Costa, F., Shah, S. A., Saunders, S. J., Barrangou, R., Brouns, S. J. J., Charpentier, E., Haft, D. H., Horvath, P., Moineau, S., Mojica, F. J. M., Terns, R. M., Terns, M. P., White, M. F., Yakunin, A. F., Garrett, R. A., van der Oost, J., … Koonin, E. V. (2015). An updated evolutionary classification of CRISPR-Cas systems. Nat Rev Microbiol, 13(11), 722–736.
Saunders, S. J. (2014). Computational analyses of post-transcriptional regulatory mechanisms [PhD Thesis]. Albert-Ludwigs-University Freiburg.
Maticzka, D., Lange, S. J., Costa, F., & Backofen, R. (2014). GraphProt: modeling binding preferences of RNA-binding proteins. Genome Biol, 15(1), R17.
Brendel, J., Stoll, B., Lange, S. J., Sharma, K., Lenz, C., Stachler, A.-E., Maier, L.-K., Richter, H., Nickel, L., Schmitz, R. A., Randau, L., Allers, T., Urlaub, H., Backofen, R., & Marchfelder, A. (2014). A complex of Cas proteins 5, 6, and 7 is required for the biogenesis and stability of crRNAs in Haloferax volcanii. JBC, 289(10), 7164–7177.
Alkhnbashi, O. S., Costa, F., Shah, S. A., Garrett, R. A., Saunders, S. J., & Backofen, R. (2014). CRISPRstrand: predicting repeat orientations to determine the crRNA-encoding strand at CRISPR loci. Bioinformatics, 30(17), i489–i496.
Richter, H., Lange, S. J., Backofen, R., & Randau, L. (2013). Comparative analysis of Cas6b processing and CRISPR RNA stability. RNA Biology, 10(5), 700–707.
Scholz, I., Lange, S. J., Hein, S., Hess, W. R., & Backofen, R. (2013). CRISPR-Cas Systems in the Cyanobacterium Synechocystis sp. PCC6803 Exhibit Distinct Processing Pathways Involving at Least Two Cas6 and a Cmr2 Protein. PLoS One, 8(2), e56470.
Maier, L.-K., Lange, S. J., Stoll, B., Haas, K. A., Fischer, S., Fischer, E., Duchardt-Ferner, E., Wohnert, J., Backofen, R., & Marchfelder, A. (2013). Essential requirements for the detection and degradation of invaders by the Haloferax volcanii CRISPR/Cas system I-B. RNA Biology, 10(5), 865–874.
Nickel, L., Weidenbach, K., Jager, D., Backofen, R., Lange, S. J., Heidrich, N., & Schmitz, R. A. (2013). Two CRISPR-Cas systems in Methanosarcina mazei strain Go1 display common processing features despite belonging to different types I and III. RNA Biol, 10(5), 779–791.
Lange, S. J., Alkhnbashi, O. S., Rose, D., Will, S., & Backofen, R. (2013). CRISPRmap: an automated classification of repeat conservation in prokaryotic adaptive immune systems. NAR, 41(17), 8034–8044.
Stoll, B., Maier, L.-K., Lange, S. J., Brendel, J., Fischer, S., Backofen, R., & Marchfelder, A. (2013). Requirements for a successful defence reaction by the CRISPR-Cas subtype I-B system. Biochem Soc Trans, 41(6), 1444–1448.
Lange, S. J., Maticzka, D., Möhl, M., Gagnon, J. N., Brown, C. M., & Backofen, R. (2012). Global or local? Predicting secondary structure and accessibility in mRNAs. NAR, 40(12), 5215–5226.
Wittkop, T., Emig, D., Lange, S., Rahmann, S., Albrecht, M., Morris, J. H., Bocker, S., Stoye, J., & Baumbach, J. (2010). Partitioning biological data with transitivity clustering. Nat Methods, 7(6), 419–420.
Albaum, S. P., Neuweger, H., Franzel, B., Lange, S., Mertens, D., Trotschel, C., Wolters, D., Kalinowski, J., Nattkemper, T. W., & Goesmann, A. (2009). Qupe–a Rich Internet Application to take a step forward in the analysis of mass spectrometry-based quantitative proteomics experiments. Bioinformatics, 25(23), 3128–3134.
Baumbach, J., Bunkowski, A., Lange, S., Oberwahrenbrock, T., Kleinbölting, N., Rahmann, S., & Baumbach, J. I. (2007). IMS2 – An integrated medical software system for early lung cancer detection using ion mobility spectrometry data of human breath. Journal of Integrative Bioinformatics, 4(3), 75.
Team member

Contact Information

Address: Coreva Scientific GmbH & Co KG,
Im Mühlenbruch 1, 53639 Königswinter,
North Rhine-Westphalia Germany

Phone: +49 (0)22237818010
E-Mail: enquiry [@] Coreva – scientific . com

Team publications
Team publications